Skip to main content

Inflammatory Protein Tied to Depression in Diabetes

People with both type-1 and type-2 diabetes have an increased risk of developing depression, but the reasons for this remain poorly understood.

Now a new study published in the journal Endocrine Connections finds that depression in type-1 diabetes patients is linked to higher levels of an inflammatory protein known as galectin-3.

The findings suggest that measuring levels of galectin-3 could be useful for diagnosis of depression or perhaps as a new target for treating depression associated with type-1 diabetes.

Galectin-3 is a key protein involved in producing the inflammatory immune system responses that are necessary to repair tissue damage throughout the body in response to injury or disease. However, increased levels of galectin-3 have also been associated with a greater risk of inflammatory disorders such as Alzheimer’s disease or cardiovascular disease.

And although prior research has shown that both depression and diabetes may be linked to increased levels of inflammation in the body, the role of galectin-3 has not been investigated in either condition until now.

For the study, the researchers measured the galectin-3 levels of 283 men and women, aged 18-59, with type-1 diabetes, for at least one year. Incidence of depression in these patients was self-reported and assessed using the Hospital Anxiety and Depression Scale-Depression subscale and possible confounding influences of lifestyle factors including heart disease, smoking or poorly managed diabetes were accounted for in the analysis.

The findings revealed that both men and women with type-1 diabetes and depression had significantly higher galectin-3 levels.

“We found that people with type-1 diabetes and depression had higher galectin-3 levels, yet no other diabetes-related metabolic changes could account for these elevated levels,” said Dr. Eva Olga Melin and colleagues at Lund University in Sweden.

While the findings indicate that galectin-3 levels are associated with diabetes and depression, the study does not show a distinct causative relationship. The researchers now plan to study the link between type-1 diabetes, depression and galectin-3 using larger, long-term studies.

Specifically, they plan to investigate how galectin-3 levels are linked to the increased risk of depression, what inflammatory processes are altered, and whether they can be targeted to treat depression.

“Depression is a common disorder with very serious and debilitating consequences, so these findings suggest that further investigating the role of galectin-3 could lead to improved diagnosis and maybe better treatment outcomes for patients in the future,” said Melin.

Source: Society for Endocrinology



from Psych Central News https://ift.tt/2JAKkyX
via IFTTT

Become a patron of The Carlisle Wellness Network. Show everyone that you think this service is worth at least a buck. Go to; https://www.patreon.com/carlislewellness and pledge one dollar per month and help improve the resources it takes to gather the articles you see here as well as create fresh content including interviews an podcasts. We only need one dollar per month from all of our patrons to give The Carlisle Wellness Network a bright furture in the health and wellness social media ecosystem.

Comments

Popular posts from this blog

PET Imaging Agent Can ID Good Candidates for Depression Drug

A new brain imaging agent could reveal — before any treatment has been prescribed — whether a patient with major depressive disorder (MDD) is likely to respond to a particular antidepressant, according to a new study published in The Journal of Nuclear Medicine. No such marker is currently available in clinical psychiatry.Escitalopram (Lexapro), a selective serotonin reuptake inhibitor (SSRI), can be an effective MDD treatment for some patients, but not all. During  positron emission tomography (PET) test, the tracer 11C-DASB targets the serotonin transporter protein (5-HTT) in the amygdala of the brain, a region associated with emotional processing.In the study, patients shown to have less 5-HTT protein were those who later experienced relief from escitalopram.“MDD is a heterogeneous disorder, which makes it extremely difficult to treat effectively,” said researcher Mala R. Ananth, a graduate student at Stony Brook University in Stony Brook, N.Y.“Optimizing treatment is challenging a…

Reducing Alzheimer’s Stigma Could Enhance Research

A new study suggests ongoing research on Alzheimer’s disease may be challenged by the stigma associated with the disease. This concern comes from the results of a national survey which discovered people may be afraid to admit they have early stage Alzheimer’s because of fear of discrimination — especially potential limitations on their health insurance.Researchers say these fears can hopefully be overcome by the development of new policies to protect individuals. Nondisclosure of early symptoms that may or may not be Alzheimer’s hinders a individuals ability to obtain timely care. Additionally, a person may miss the opportunity to participate in clinical studies that discover potential therapies.The finding are the results of a national survey about what beliefs, attitudes and expectations are most often associated with Alzheimer’s disease. The survey results appear in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.“We found that concerns about discrimination a…

Hair Pulling, Nail Biting, Skin Peeling and Biting

All my life I’ve bitten my nails. It’s caused me a lot of trouble, especially with my bipolar mother who has always thought screaming and shouting at me (and often a smack when I was younger) would make me stop.At around 7 I also started biting and peeling the skin on my fingers which has caused a lot of social and health issues for me from being to ashamed to join in with prayers at school, to getting my fingers getting a fungal infection causing long lasting damage to my fingers.Soon after I started to pull out the tiny hairs on my legs during school assembles and by 12 I began to pull my eyebrow hair out.How can I stop doing this to myself? I don’t even realise I’m doing it half the time (I started biting the skin around my fingers just writing this and caused it to bleed a little). I’m afraid to bring this up with my parents because of how they have reacted in the past and I’m far too embarrassed to ask anyone I would typically trust. It has severally impacted how I interact with …