People with major depressive disorder (MDD) experience more intense negative emotions while recalling painful memories compared to non-depressed people, according to a new study published in the journal Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.And although those with MDD were able to turn down their negative emotions about as well as non-depressed people, they used different brain circuits to do so.The new findings pinpoint brain differences in MDD associated with the processing of autobiographical memories — one’s memories of personal events and knowledge of one’s life — that help us develop our sense of self and guide our interactions with the world around us.“This study provides new insights into the changes in brain function that are present in major depression,” said journal editor Cameron Carter, M.D. “It shows differences in how memory systems are engaged during emotion processing in depression and how people with the disorder must regulate these systems i…
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